premier source of excellent articles for young and experienced scientists.Additionally, each published article is promoted to researchers working in the same field of Earth Sciences. Free language correction is provided to authors from non-English speaking regions. Open Geosciences is designed to facilitate the exchange of ideas between experienced and young researchers from different countries. Cumulatively, these findings demonstrate that EWSR1 is a negative regulator of B cell responses.The aim of the journal is to become the premier source of high quality research from all over the world. Notably, EWSR1 deficiency did not affect the proliferation or survival of GC B cells but instead resulted in the generation of increased numbers of precursor GC B cells. Here, we demonstrate that 1) B cell–specific deletion of EWSR1 had no effect on generation of mature B cell subsets or basal immunoglobulin levels in naïve mice, 2) repression or ablation of EWSR1 in B cells promoted expansion of MHV68 latently infected GC B cells, and 3) B cell–specific deletion of EWSR1 during a normal immune response to nonviral antigen resulted in significantly elevated numbers of antigen-specific GC B cells, plasma cells, and circulating antibodies. A function for EWSR1 in B cell responses has not been previously reported. EWSR1 is a transcription and splicing regulator that is recognized for its involvement as a fusion protein in Ewing sarcoma. We previously demonstrated that the MHV68 microRNA (miRNA) mghv-miR-M1-7-5p represses host EWSR1 (Ewing sarcoma breakpoint region 1) to promote B cell infection. Gammaherpesviruses such as Epstein–Barr virus (EBV) and murine gammaherpesvirus 68 (MHV68) utilize numerous armaments to drive infected naïve B cells, independent of antigen, through GC reactions to expand the latently infected B cell population and establish a stable latency reservoir. Tight regulation of the GC is essential due to the inherent risks of tumorigenesis and autoimmunity posed by inappropriate GC B cell processes. The germinal center (GC) plays a central role in the generation of antigen-specific B cells and antibodies.
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